AIDS: an Immune Response against the Immune System. Role of a Precise Tridimensional Molecular Mimicry
Identifieur interne : 003603 ( Main/Exploration ); précédent : 003602; suivant : 003604AIDS: an Immune Response against the Immune System. Role of a Precise Tridimensional Molecular Mimicry
Auteurs : Pierre-François Serres [France]Source :
- Journal of Autoimmunity [ 0896-8411 ] ; 2001.
English descriptors
- KwdEn :
- Teeft :
- Acid clusters, Analogous clusters, Analogous sites, Antigenic, Antigenic sites, Atomic structure, Autoimmune consequences, Corresponding sequences, Ectodomain, Elisa, Feline virus, Front view, Hiv1, Human virus, Immune, Immune response, Immune system, Immunodominant, Immunodominant sites, Immunosuppressive lentiviruses, Institut fournier, Mimicry, Molecular mimicry, Physical similarities, Receptor, Same positions, Serres, Simian virus, Spatial superposition, Structural analogies, Subunit, Transmembrane, Transmembrane envelope protein, Transmembrane protein, Trimeric, Trimeric ectodomain.
Abstract
Abstract: This study describes some of the expected autoimmune consequences of a recently described virus–host molecular mimicry in patients infected with human immunodeficiency virus (HIV). Some physical and structural analogies have been recently identified between some precise antigenic sites of the trimeric ectodomain of the transmembrane envelope protein of AIDS-associated lentiviruses (HIV, Simian immunodeficiency virus and feline immunodeficiency virus) and some precise and crucial interleukin 2 (IL-2) antigenic sites of the corresponding infected species (man, monkey, cat). As expected, HIV-positive sera recognize human IL-2, and a cross-reactivity was found between the structurally and physically analogous antigenic sites of GP41 (HIV1) and human IL-2. The possible impact on AIDS-associated disorders of this tridimensional GP41 (HIV1)/human IL-2 molecular mimicry is suggested.
Url:
DOI: 10.1006/jaut.2000.0500
Affiliations:
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Role of a Precise Tridimensional Molecular Mimicry</title><author><name sortKey="Serres, Pierre Francois" sort="Serres, Pierre Francois" uniqKey="Serres P" first="Pierre-François" last="Serres">Pierre-François Serres</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>HIPPOCAMPE (Research and Development, Human and Veterinary Medicine), 50–52 Avenue Chanoine Cartellier, 69230, Saint Genis Laval</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint Genis Laval</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Autoimmunity</title><title level="j" type="abbrev">YJAUT</title><idno type="ISSN">0896-8411</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="287">287</biblScope><biblScope unit="page" to="291">291</biblScope></imprint><idno type="ISSN">0896-8411</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0896-8411</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS, cross reactivity, IL-2, molecular mimicry, transmembrane envelope protein</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acid clusters</term><term>Analogous clusters</term><term>Analogous sites</term><term>Antigenic</term><term>Antigenic sites</term><term>Atomic structure</term><term>Autoimmune consequences</term><term>Corresponding sequences</term><term>Ectodomain</term><term>Elisa</term><term>Feline virus</term><term>Front view</term><term>Hiv1</term><term>Human virus</term><term>Immune</term><term>Immune response</term><term>Immune system</term><term>Immunodominant</term><term>Immunodominant sites</term><term>Immunosuppressive lentiviruses</term><term>Institut fournier</term><term>Mimicry</term><term>Molecular mimicry</term><term>Physical similarities</term><term>Receptor</term><term>Same positions</term><term>Serres</term><term>Simian virus</term><term>Spatial superposition</term><term>Structural analogies</term><term>Subunit</term><term>Transmembrane</term><term>Transmembrane envelope protein</term><term>Transmembrane protein</term><term>Trimeric</term><term>Trimeric ectodomain</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This study describes some of the expected autoimmune consequences of a recently described virus–host molecular mimicry in patients infected with human immunodeficiency virus (HIV). Some physical and structural analogies have been recently identified between some precise antigenic sites of the trimeric ectodomain of the transmembrane envelope protein of AIDS-associated lentiviruses (HIV, Simian immunodeficiency virus and feline immunodeficiency virus) and some precise and crucial interleukin 2 (IL-2) antigenic sites of the corresponding infected species (man, monkey, cat). As expected, HIV-positive sera recognize human IL-2, and a cross-reactivity was found between the structurally and physically analogous antigenic sites of GP41 (HIV1) and human IL-2. The possible impact on AIDS-associated disorders of this tridimensional GP41 (HIV1)/human IL-2 molecular mimicry is suggested.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Saint Genis Laval</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Serres, Pierre Francois" sort="Serres, Pierre Francois" uniqKey="Serres P" first="Pierre-François" last="Serres">Pierre-François Serres</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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